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Scientists at the University of California San Diego School of Medicine have unveiled groundbreaking insights into the progression of liver cancer, a disease that ranks as the sixth most commonly diagnosed cancer and the fourth leading cause of cancer-related deaths globally. This research delves into the mechanisms that drive the transition from metabolic dysfunction-associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC), revealing the intricate relationship between cellular metabolism and DNA damage. The findings not only enhance our understanding of cancer origins but also open potential avenues for prevention and treatment, fundamentally linking dietary habits with cancer’s interplay at the cellular level.…

Researchers at the University of Iowa have delivered a compelling message emphasizing the critical need to assess patients regarding their physical activity levels. Findings from a comprehensive study reveal a robust link between physical activity and a substantial reduction in the risk of chronic diseases. Led by Lucas Carr, an esteemed associate professor in the Department of Health and Human Physiology, the research assessed data from over 7,000 patients at the University of Iowa Health Care Medical Center. Participants in this important survey provided insights through a structured questionnaire focusing on their exercise habits. The analysis indicated that individuals engaging…

A groundbreaking study by Professors Mario Mikulincer and Ron Shachar from Reichman University, along with doctoral student Haran Einam, has unveiled compelling insights into the profound impact storytelling has on individual well-being. Conducted across diverse populations in Israel and the United States, this research establishes a direct correlation between storytelling proficiency and the overall sense of meaning and satisfaction in life. The participants in the study demonstrated how their storytelling abilities enhance not just their personal experiences but also influence their external perspectives and interactions with others. The researchers adopted a multifaceted approach to assess storytelling capability among participants. This…

by Gertrud U. Rey Flu season is in full swing, and hospitalizations related to influenza virus infection are on the rise. During the 2009 “swine flu” pandemic it became evident that diabetes and obesity increase one’s risk for severe influenza disease, a correlation that was also later observed in the context of COVID-19. A series of recent studies led by Kirsty Short at the University of Queensland have shed some light on the mechanisms that implicate diabetes and obesity as causal risk factors in severe influenza. Diabetes is a metabolic disorder that is characterized by the reduced ability to produce…

Image source: Discovery Institute. The Icons of Evolution that Dr Jonathan Wells wrote about 24 years ago have not been put out of our misery. Like denizens of Zombie Science, they keep reappearing in popular science articles, cartoons, and even scientific journals. The perpetrators should know better. There is no excuse for perpetuating the mythic fables that Darwinians have used to popularize just-so stories of how natural selection supposedly works (but doesn’t under the spotlight). Two of the icons appeared in publications recently. The old stories are retold without remorse, in spite of the fact that new evidence contradicts them. The Peppered Myth Still…

Insilico Medicine has recently announced a significant milestone in its drug discovery journey with the nomination of ISM1745 as a preclinical candidate targeted at treating cancers that have lost the MTAP gene. This groundbreaking research positions ISM1745 as a competitive player in the landscape of targeted cancer therapies, particularly due to its unique mechanism of action as a MTA cooperative PRMT5 inhibitor. The nomination of this compound underscores the relevance of generative artificial intelligence in modern drug development, as it was realized through the cutting-edge platform called Chemistry42, which combines various advanced generative models to facilitate the design of novel…

Newsletter Signup – Under Article / In Page”*” indicates required fields Partnerships in the biopharma industry have been a long-standing measure of research and development (R&D). Last month saw a number of alliances forming in a range of therapeutic spaces but there has been one serial collaborator that stands out – GSK. The British pharma giant seems to have embarked on a dealmaking journey across the globe to strengthen its presence in various fields.GSK goes big in December 2024 with licensing dealsAmong GSK’s latest conquests is nabbing the licensing rights to DB-1324, an antibody-drug conjugate (ADC) from Chinese biotech Duality…

Credit: Photo Mike Gillam, from Science Advances (2025). DOI: 10.1126/sciadv.ado4140 Marsupial moles are perhaps Australia’s most bizarre mammals. Known as “itjaritjari” to the Indigenous Aṉangu people and featuring prominently in their tales, the marsupial mole is rarely observed, making any sighting a rare event. Now, our team, led by Dr. Stephen Frankenberg and Professor Andrew Pask, has begun to unearth some of the marsupial mole’s deepest evolutionary secrets by studying its genome for the first time. Adapting to a life down under Marsupial moles live in the deep deserts of Australia, making their way not by digging permanent tunnels but…

Recent advancements in artificial intelligence have generated considerable excitement, particularly regarding the potential of large language models, like ChatGPT, to revolutionize healthcare by significantly reducing clinician workload. These AI tools are touted as capable of triaging patients, gathering medical histories, and even offering preliminary diagnoses, which, in theory, could allow healthcare professionals to dedicate more time to complex cases. However, a recently published study led by researchers from Harvard Medical School and Stanford University sheds light on a troubling gap between the impressive performance of these models on standardized medical tests and their effectiveness in real-world clinical scenarios. The study,…

A recent groundbreaking study published in the esteemed journal Nature Medicine has emerged from the innovative research team at Karolinska Institutet in Sweden, revealing a significant leap in medical diagnostics through the use of artificial intelligence. This study demonstrates that AI-based models have the capacity to surpass human experts when it comes to identifying ovarian cancer in ultrasound images. The implications of this research could fundamentally alter how ovarian cancer is detected and managed worldwide, particularly in areas where access to specialized ultrasound expertise is limited. The prevalence of ovarian tumors remains a critical concern in women’s health, often leading…