Author: admin123TerRe

Scientists from the Kavli Institute of Delft University of Technology and the IMP Vienna Biocenter discovered a new property of the molecular motors that shape our chromosomes. While six years ago they found that these so-called SMC motor proteins make long loops in our DNA, they now discovered that these motors also put significant twists into the loops that they form. These findings help us better understand the structure and function of our chromosomes. They also provide insight into how disruption of twisted DNA looping can affect health-;for instance, in developmental diseases like ‘cohesinopathies’. The scientists published their findings in…

Newsletter Signup – Under Article / In Page”*” indicates required fields The companies Metsera, Alentis Therapeutics, and Adcendo bagged the biggest private biotech investments in November 2024. Around the world, oncology, central nervous system (CNS), and genetic disorder players attracted the biggest funding rounds overall.Biggest biotech investments by value in November 2024The biggest private biotech funding round of November 2024 went to Metsera, which raised $215 million in series B funding. The company is focused on advancing the next generation of therapies for obesity and metabolic diseases, and the proceeds from this financing round will go toward further advancing its…

Enthusiastic about science communication and looking for a chance to broaden your writing experience alongside your research activities? The Node, the community site for developmental and stem cell biologists, is looking to appoint three correspondents who will play a key role in developing and writing content over the coming year. In 2024, we have been working with Alex Neaverson, who’s used her artistic talents to create illustrations for the Node. You can check out Alex’s illustrations about Rita-Levi Montalcini’s extraordinary life, and the post about the work of Millie Race, winner of the Young Embryologist Network Sammy Lee Award. Thank…

Phylogeny, photo documentation, and geographical distribution of Psilocybe ochraceocentrata. Credit: Evolutionary Biology (2024). DOI: 10.1101/2024.12.03.626483 A team of biologists, mycologists and microbiologists in the U.S., South Africa and Zimbabwe reports that a species of mushroom growing in parts of Africa is the closest relative of Psilocybe cubensis, the most widespread hallucinogenic mushroom known to science. In their study, posted to the bioRxiv preprint server, the team collected samples of both types of mushrooms, sequenced them and then compared them to see how alike they were. P. cubensis is known by many names around the globe, including magic mushrooms, shrooms or…

ambiom is a life science commercial-advisory business development company based in the Slovakian capital of Bratislava.The company helps its corporate clients with their product strategy, in- and out-licensing efforts, including asset valuation (NPV, rNPV), M&A scouting, complex due diligence and dealmaking.ambiom also provides input on regulatory matters, support in pricing and reimbursement decisions and communication with decision-making authorities. The company guides products from the beginning – the basic science – all the way to commercialization or spin-offs.Our guest on the podcast this week is the founder and CEO of ambiom, Adam Marťák. We discuss the biotech scene in eastern Europe,…

Citation: Kinsler G, Li Y, Sherlock G, Petrov DA (2024) A high-resolution two-step evolution experiment in yeast reveals a shift from pleiotropic to modular adaptation. PLoS Biol 22(12): e3002848. https://doi.org/10.1371/journal.pbio.3002848Academic Editor: J. Arjan G. M. de Visser, Wageningen University, NETHERLANDS, KINGDOM OF THEReceived: April 19, 2024; Accepted: September 17, 2024; Published: December 5, 2024Copyright: © 2024 Kinsler et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Data Availability: All relevant data are within the…

This is just a quick note to say that I will be on a panel at San Diego Comic Con again this year and would like to invite you all to come say hi! Once again, the panel is organized by the visionary Steve Broback, head of Dent the Future, an organization committed to advancing new and creative ideas throughout society, especially in technology. Given my frequent participation in Dent events, they also seem to be keenly interested in genetics and its future. Our panel is about the science of Avatar: The Way of Water. Joining me will be Michelle…

Newsletter Signup – Under Article / In Page”*” indicates required fields When German scientists posted data in 2022 showing that CAR-T cell therapy could be effective in treating systemic lupus erythematosus, interest in the field quickly took off. More recently, spurring interest even further, the researchers posted an update in February 2024, showing results from a case series in which 15 autoimmune disease patients, eight of which had systemic lupus erythematosus, all achieved complete remission after receiving a single infusion of CAR-T therapy.Lupus, which affects around five million people worldwide, occurs when the immune system attacks its own tissues. The…

AbstractOutbreaks of fungal diseases have devastated plants and animals throughout history. Over the past century, the repeated emergence of coffee wilt disease caused by the fungal pathogen Fusarium xylarioides severely impacted coffee production across sub-Saharan Africa. To improve the disease management of such pathogens, it is crucial to understand their genetic structure and evolutionary potential. We compared the genomes of 13 historic strains spanning 6 decades and multiple disease outbreaks to investigate population structure and host specialisation. We found that F. xylarioides comprised at least 4 distinct lineages: 1 host-specific to Coffea arabica, 1 to C. canephora var. robusta, and…

Post provided by Coralie Williams Have you ever wondered if your simulation study could be replicated? The replication crisis has been a hot topic in empirical research for years, but it’s only recently that we’ve started discussing it in statistical method research (Boulesteix et al., 2020; Luijken et al., 2024). Methodological research often relies on simulations – computer experiments that assess how well statistical methods perform under predefined conditions. Simulations are a valuable tool for evaluation and comparison, but just like any scientific experiment, they face challenges with reproducibility. These challenges could be due to two key issues: (1) selective…