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Newsletter Signup – Under Article / In Page”*” indicates required fields Partnerships in the biopharma industry have been a long-standing measure of research and development (R&D). Last month saw a number of alliances forming in a range of therapeutic spaces but there has been one serial collaborator that stands out – GSK. The British pharma giant seems to have embarked on a dealmaking journey across the globe to strengthen its presence in various fields.GSK goes big in December 2024 with licensing dealsAmong GSK’s latest conquests is nabbing the licensing rights to DB-1324, an antibody-drug conjugate (ADC) from Chinese biotech Duality…

Credit: Photo Mike Gillam, from Science Advances (2025). DOI: 10.1126/sciadv.ado4140 Marsupial moles are perhaps Australia’s most bizarre mammals. Known as “itjaritjari” to the Indigenous Aṉangu people and featuring prominently in their tales, the marsupial mole is rarely observed, making any sighting a rare event. Now, our team, led by Dr. Stephen Frankenberg and Professor Andrew Pask, has begun to unearth some of the marsupial mole’s deepest evolutionary secrets by studying its genome for the first time. Adapting to a life down under Marsupial moles live in the deep deserts of Australia, making their way not by digging permanent tunnels but…

Recent advancements in artificial intelligence have generated considerable excitement, particularly regarding the potential of large language models, like ChatGPT, to revolutionize healthcare by significantly reducing clinician workload. These AI tools are touted as capable of triaging patients, gathering medical histories, and even offering preliminary diagnoses, which, in theory, could allow healthcare professionals to dedicate more time to complex cases. However, a recently published study led by researchers from Harvard Medical School and Stanford University sheds light on a troubling gap between the impressive performance of these models on standardized medical tests and their effectiveness in real-world clinical scenarios. The study,…

A recent groundbreaking study published in the esteemed journal Nature Medicine has emerged from the innovative research team at Karolinska Institutet in Sweden, revealing a significant leap in medical diagnostics through the use of artificial intelligence. This study demonstrates that AI-based models have the capacity to surpass human experts when it comes to identifying ovarian cancer in ultrasound images. The implications of this research could fundamentally alter how ovarian cancer is detected and managed worldwide, particularly in areas where access to specialized ultrasound expertise is limited. The prevalence of ovarian tumors remains a critical concern in women’s health, often leading…

Recent research has illuminated the potential benefits of psilocybin, a naturally occurring compound found in certain species of psychedelic mushrooms, particularly in the context of psychological health for cancer patients and individuals grappling with alcohol use disorder. The studies reveal that a modest number of psilocybin doses, when administered with psychotherapeutic support, can result in noteworthy enhancements in mental well-being and personality traits. These findings are especially significant given the growing interest in the therapeutic applications of psychedelics in treating various psychological conditions. The first of these studies, conducted by a team at NYU Langone Health and published in the…

A recent breakthrough in cancer research has unveiled significant insights into the mechanisms of clear cell renal cell carcinoma (ccRCC), the most prevalent form of kidney cancer among adults. Researchers from Cold Spring Harbor Laboratory (CSHL) and the University of Pennsylvania have identified distinctive patterns of cellular structures known as nuclear speckles, which may hold the key to understanding patient variability in treatment responses. This important discovery could pave the way for more personalized cancer therapies, reducing the unpredictable nature of treatment efficacy in patients afflicted by ccRCC. The critical discovery was made by CSHL Assistant Professor Katherine Alexander and…

Hula hooping has long been seen as a playful activity, often associated with childhood and leisure. However, beneath this seemingly simple pastime lies a complex interplay of physics and mathematics that has intrigued researchers for years. Recent studies conducted by a team of mathematicians have peeled back the layers on this phenomenon, uncovering insights that not only provide answers to longstanding questions about body types and hooping techniques but also suggest avenues for innovation in energy harvesting and robotics. The study, spearheaded by Leif Ristroph, a mathematician and associate professor at New York University’s Courant Institute of Mathematical Sciences, delves…

Evolution Evolving: The Developmental Origins of Adaptation and Biodiversity Kevin H. Lala, Tobias Uller, Nathalie Feiner, Marcus W. Feldman and Scott F. Gilbert Princeton University Press, 2024. evolutionevolving.org. Some of you may have been so fortunate as to receive gift cards for Amazon.com or local bookstores in your Christmas stockings. While I wouldn’t think of dissuading you from purchasing the latest Louise Perry mystery or the memoirs of pre-eminent singers and chefs, I would recommend that you consider a new intellectual thriller, Evolution Evolving. Imagine if two outstanding evolutionary biologists realized that evolutionary theory cannot explain adaptation and biodiversity without…

Researchers have come up with a new way to identify more infectious variants of viruses or bacteria that start spreading in humans – including those causing flu, COVID, whooping cough and tuberculosis. The new approach uses samples from infected humans to allow real-time monitoring of pathogens circulating in human populations, and enable vaccine-evading bugs to be quickly and automatically identified. This could inform the development of vaccines that are more effective in preventing disease. The approach can also quickly detect emerging variants with resistance to antibiotics. This could inform the choice of treatment for people who become infected – and…

A joint research group team led by Sayuri Tsukahara and Tetsuji Kakutani of the University of Tokyo has clarified a mechanism of how retrotransposons, genetic elements that can “jump around” chromosomes and are known drivers of evolution, preferentially insert in the centromere. The findings were published in the journal Nature. The centromere is the thinnest part of the chromosome that divides it into a long and short arm, much like how the waist separates the upper and lower body. Its role in transmitting information via cell division has been preserved across eukaryotes, cells with membrane-bound nuclei. This is despite the…