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Newsletter Signup – Under Article / In Page”*” indicates required fields Last year, we documented nine biotechs we thought you should watch in 2024. Now, as the year has flown by and the end of 2024 is approaching, biotech companies will be setting out their plans for next year as they continue to work towards bringing their innovative therapies through the clinic and to the market in an attempt to bring new and groundbreaking medicines to patients suffering from debilitating diseases. In this article, we take a look at 10 biotech companies we think are worth keeping an eye out…

AbstractThe interaction between cancer cells and the extracellular matrix (ECM) plays a pivotal role in tumour progression. While the extracellular degradation of ECM proteins has been well characterised, ECM endocytosis and its impact on cancer cell progression, migration, and metastasis is poorly understood. ECM internalisation is increased in invasive breast cancer cells, suggesting it may support invasiveness. However, current high-throughput approaches mainly focus on cells grown on plastic in 2D, making it difficult to apply these to the study of ECM dynamics. Here, we developed a high-content screening assay to study ECM uptake, based on the of use automated ECM…

Credit: Shodo Mtow Researchers at Meijo University and University of Tsukuba collected and taxonomically re-examined numerous enigmatic jumping bristletails. These were first reported 75 years ago. The team observed extreme specialization in the external genitalia of the males and discovered that this species belongs to a unique group, potentially representing a primitive state leading to “copulation” during evolutionary development. The study is published in Zootaxa. Insects account for 75% of all animal species, making them the most diverse animal group. Of these, 99% belong to Pterygota, which have acquired wings, while the remaining 1% consist of primitive groups collectively known…

AbstractBacterial noncoding RNAs fulfill a variety of cellular functions as catalysts, as scaffolds in protein complexes or as regulators of gene expression. They often exhibit complex tertiary structures that are a key determinant of their biochemical function. Here, we characterize the structured “raiA motif” RNA from Clostridioides difficile, which is conserved in more than 2,500 bacterial species from the phyla Bacillota and Actinomycetota. We show that its transcript abundance and stability in exponentially growing bacteria rivals that of ribosomal RNAs. Deletion of the “raiA motif” RNA is associated with delayed transition into stationary phase, and changes in stationary phase pathways…

This Saturday (30-March), I will appear as a forensic DNA expert on an episode of 48 hours. The episode will run at 10p (EDT) on CBS and Paramount+ (and available any time thereafter on P+). EDIT: Here is the episode. This is a very disturbing case. In early 2000, Bob Dorotik was found brutally murdered along the side of the road near San Diego. According to his wife and others, he had gone out jogging and never returned. Within hours, the San Diego County Sheriff’s Department began focusing on his wife Jane as their prime suspect. Within a few days,…

Citation: Xu X, Jiang J (2024) Engineering microbiomes for enhanced bioremediation. PLoS Biol 22(12): e3002951. https://doi.org/10.1371/journal.pbio.3002951Published: December 16, 2024Copyright: © 2024 Xu, Jiang. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Funding: This work was supported by grants from the National Key R&D Program of China (2022YFA0912501 to J.J.), the National Natural Science Foundation of China (42177031 and 42477008 to X.X.), and the Fundamental Research Funds for the Central Universities (KJYQ2024020 to X.X.). The funders…

Citation: Zhao S, Jiang X, Li N, Wang T (2024) SLMO transfers phosphatidylserine between the outer and inner mitochondrial membrane in Drosophila. PLoS Biol 22(12): e3002941. https://doi.org/10.1371/journal.pbio.3002941Academic Editor: Alex P. Gould, The Francis Crick Institute, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELANDReceived: April 8, 2024; Accepted: November 15, 2024; Published: December 16, 2024Copyright: © 2024 Zhao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Data Availability: All relevant data are within the…

In this series, we explore the unique experiences of field ecologists conducting research in remote field stations during the holiday season. Through personal stories and reflections, our contributors share what it’s like to conduct scientific work in remote, biodiverse environments, where the challenges of research intersect with the spirit of the holidays. From the solitude of secluded field stations to unexpected festive moments in the wild, this series highlights the resilience and dedication of ecologists and evolutionary biologists working in these remarkable regions of the world. Here, researchers from the Succulent Karoo Research Station, relay their field experiences in Namaqualand…

Photo credit: Benjamin Lizardo via Unsplash. A recent episode of Long Story Short lampoons popular science coverage on the origin of life. The coverage tends to be strong on storytelling but weaker on fact. As if narrating an explorer’s journey, complete with pith helmet, Long Story warns, “The first sort of made-up thing you should be on the lookout for is what we call Imagination Story-Time Land.” There’s also “Half-Truthiland” and “Outright Falsehood Jungle.” A scan of recent science news seems to confirm Long Story on this. Researchers are presented as making confident progress in solving the mystery of how life arose…while being at the same…

The appropriate utilization of animals within non-clinical research is always on the minds of drug developers. Lovelace Biomedical is always working with its team of experts to stay in touch with the current regulatory landscape and evaluating novel approaches to reduce the number of animals required in drug development. With the recent changes in the FDA Modernization Act Lovelace’s approach continues to evolve and some details can be found in their recent article with AAPS News Magazine: Bringing Clarity and Perspective to the FDA Modernization Act 2.0. Halo, sobat pengemar slots pernahkah denger istilah “slot gaco”? jika belum, siap-siap jatuh…