Author: admin123TerRe

As dogs age, their owner-assessed quality of life predictably declines, with higher mortality seen at quality of life below 76% of the maximum score – though many dogs have high quality of life even when at predicted lifespan Credit: Juli Leonard for the Canine Neuroaging Program, CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/) As dogs age, their owner-assessed quality of life predictably declines, with higher mortality seen at quality of life below 76% of the maximum score – though many dogs have high quality of life even when at predicted lifespan### Article URL:  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0301181 Article Title: Cross-sectional and longitudinal analysis of health-related quality of…

 The Biologists @ 100 conference, happening 24-27 March 2025 in Liverpool, UK, will have a dedicated half-day event specifically for early-career researchers (ECRs), in the afternoon of 24 March 2025. The ECR event will focus on career opportunities both inside and outside of academia. We’re excited to have Richard Sever, the co-founder of bioRxiv and medRxiv, as the keynote speaker at the career session. You’ll also hear from  professionals from a diverse spread of career paths to discuss how skills developed during your research career can be applied in a number of different roles. There will also be food and drinks…

Our ‘Featured resource’ series aims to shine a light on the resources that support our research – the unsung heroes of the science world. In this post, Connie Smith and Martin Ringwald introduce the data and functionalities available at Gene Expression Database and talk about the future directions of the database. What is the Gene Expression Database (GXD)? GXD is a long-standing, freely available community resource that collects and integrates mouse gene expression data generated by biomedical researchers worldwide. Our primary emphasis is on endogenous gene expression during development, covering data from wild-type and mutant mice. Data types include RNA…

isbscience.org/news/2024/11/27/isb-developed-metabocore-offers-precision-cancer-care-faster-than-ever/  Posted on November 27, 2024 The ultimate goal of precision oncology is to provide the right cancer drug to the right patient at the right time. However, cancer is difficult to treat in part because it isn’t just one disease – every cancer is unique. Even if two people have the same type of cancer in the same organ, their tumors are different. And other important variables make precision cancer treatment challenging.  There is the sheer number of cancer drugs on the market. In the past four years alone, more than 250 oncology drugs have been approved, bringing the total…

isbscience.org/news/2024/12/03/isb-named-winner-of-2024-2025-amazon-web-services-imagine-grant-for-nonprofits/  Posted on December 3, 2024 SEATTLE — The Institute for Systems Biology (ISB) today announced it has been selected as a winner of the 2024 Amazon Web Services (AWS) IMAGINE Grant, a public grant opportunity open to registered charities in the United Kingdom and Ireland and registered 501(c) nonprofit organizations in the United States who are using technology to solve the world’s most pressing challenges. The grant will support ISB’s continued development of My Digital Gut, an online decision-support platform that will help make microbiome-informed nutrition and healthcare personalized, predictive, and preventive.  Now in its seventh year, the AWS…

isbscience.org/news/2024/12/09/2024-year-in-review/  Posted on December 9, 2024 ISB reflects on 2024 with much to celebrate: groundbreaking research published in leading scientific journals, well-earned promotions, widespread media coverage, and more. Yet, the year was profoundly marked by the loss of our beloved colleague and friend, Dr. Ilya Shmulevich, who passed away in April at age 54 from complications of acute myeloid leukemia. “Ilya’s impact on his lab, fellow faculty, ISB as a whole, and all who had the pleasure of knowing him cannot be adequately expressed. He was an outstanding scientist, mentor, colleague, collaborator, and friend,” said ISB President Dr. Jim Heath.…

Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints. The preprints this month are hosted on bioRxiv – use these links below to get to the section you want: Developmental biology Patterning & signalling Morphogenesis & mechanics Genes & genomes Stem cells, regeneration & disease modelling Plant development Evo-devo Cell Biology Modelling Tools & Resources Developmental biology | Patterning & signalling Synchronization of the segmentation clock using synthetic cell-cell signaling Akihiro Isomura, Daisuke Asanuma, Ryoichiro Kageyama Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma Odessa R. Yabut, Hector Gomez, Jessica…

Over the past 12,000 years, humans in Europe have dramatically increased their ability to digest carbohydrates, expanding the number of genes they have for enzymes that break down starch from an average of eight to more than 11, according to a new study by researchers from the U.S., Italy and United Kingdom. Over the past 12,000 years, humans in Europe have dramatically increased their ability to digest carbohydrates, expanding the number of genes they have for enzymes that break down starch from an average of eight to more than 11, according to a new study by researchers from the U.S.,…

A study of more than 200,000 tweets from 2019 and 2020 finds that anti-immigration content spreads faster than pro-immigration tweets and that a few users disproportionally generated most of the UK-based anti-immigration content. Andrea Nasuto and Francisco Rowe of the Geographic Data Science Lab at the University of Liverpool, UK, present these findings in the open-access journal PLOS ONE on September 4, 2024.Credit: Nasuto, Rowe, 2024, PLOS ONE, CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/) A study of more than 200,000 tweets from 2019 and 2020 finds that anti-immigration content spreads faster than pro-immigration tweets and that a few users disproportionally generated most of…

Poroid fungi, commonly known as “polypores,” are among the most frequently encountered fungi throughout the year because of their large size and longevity. Despite the common presence of poroid fungi in North America, most guides include only a limited selection of these fungi. Poroid Fungi of North America, by Leif Ryvarden, offers a necessary, updated account of these fungi, building on the foundational work of the original two-volume North American Polypores, by Ryvarden and R. L. Gilbertson, published in 1987. This comprehensive update incorporates more than three decades of new research, featuring detailed keys, descriptions, and vibrant color macrophotos, as well as illustrations…