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Citation: Couce A (2024) Regulatory networks may evolve to favor adaptive foresight. PLoS Biol 22(12): e3002922. https://doi.org/10.1371/journal.pbio.3002922Published: December 6, 2024Copyright: © 2024 Alejandro Couce. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Funding: A.C. acknowledges support from the Agencia Estatal de Investigación (Proyectos de I+D+i, PID2022-142857NB-I00; Centros de Excelencia “Severo Ochoa”, CEX2020-000999-S), and a Comunidad de Madrid “Talento” Fellowship (2019-T1/BIO-12882, 2023-5A/BIO-28940). The funders had no role in study design, data collection and analysis, decision to…

A groundbreaking study evaluates the feasibility, risks, and ethical considerations of creating mirror bacteria with reversed chirality, highlighting potential threats to health and ecosystems. ​​​​​​​Study: Confronting risks of mirror life. Image Credit: Volha_R/Shutterstock.com In a recent study published in Science, a team of researchers investigated and discussed the potential roadblocks to and risks of “mirror life,” where life forms are synthesized using biomolecules with reversed chirality compared to natural life. The researchers assessed the feasibility, safety concerns, and governance strategies to address the unprecedented risks posed by these synthetic life forms. Background Natural life is characterized by specific molecular chirality, with ribonucleic…

Newsletter Signup – Under Article / In Page”*” indicates required fields As the biotech industry always searches for new types of therapies that can improve on current standard-of-care treatments, glycobiology is now emerging as an area that could potentially lead to a new type of cancer immunotherapy and become an alternative approach to using conventional immune checkpoint inhibitors, a type of drug that continues to face numerous challenges. In this article, we take a look at what glycobiology is, how it can be applied to cancer immunotherapy, and which companies are currently operating in the up-and-coming field of glyco-immunology. Finding new…

Citation: Wingfield BD, Wingfield MJ (2024) Gene transfer between fungal species triggers repeated coffee wilt disease outbreaks. PLoS Biol 22(12): e3002901. https://doi.org/10.1371/journal.pbio.3002901Published: December 6, 2024Copyright: © 2024 Wingfield, Wingfield. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Funding: BDW holds a research chair which is funded by the South African Dept of Science and Innovation. MJW received no specific funding for this work. The funders had no role in study design, data collection and analysis,…

Family tree of mammals surveyed for the study, also known as a phylogeny. The branches of the tree are labeled with colors that correspond to litter size. Darker colors indicate larger litter sizes, while lighter colors (oranges) indicate smaller litter sizes. The animal outlines are, from top to bottom, rodents, rabbits, primates, cetartiodactyls (whales and most hooved animals), carnivores, bats and shrews. Credit: McBride and Monson, 2024 Twins have been rare in human history and for that reason can seem special. Many cultures associate twins with health and vitality, while others see them as a philosophical reminder of the duality…

Citation: Rodrigues NTL, Bland T, Ng K, Hirani N, Goehring NW (2024) Quantitative perturbation-phenotype maps reveal nonlinear responses underlying robustness of PAR-dependent asymmetric cell division. PLoS Biol 22(12): e3002437. https://doi.org/10.1371/journal.pbio.3002437Academic Editor: François Schweisguth, Institut Pasteur, FRANCEReceived: November 2, 2023; Accepted: October 30, 2024; Published: December 9, 2024Copyright: © 2024 Rodrigues et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Data Availability: All underlying numerical data and relevant analysis code are available at https://doi.org/10.25418/crick.27153459.Funding: This…

It might have been nice in the video or in a footnote to mention the coadaptation of the inverted retina and tapetum lucidum. For many animals, seeing in dim light conditions are enhanced or even made possible thanks to the tl and without the inverted retina, as we argued in our publication (Vee et al 2022. The glow of the night: The tapetum lucidum as a co-adaptation for the inverted retina. Bioessays), this would not have been possible. So, rather than not having a clue as to why the vertebrate retina is inverted, one clue might be in the vertebrate…

Newsletter Signup – Under Article / In Page”*” indicates required fields The penultimate month of the year saw a lot of biopharmas scouting for fellow biopharmas to advance therapies across different stages through to commercialization. Mergers and acquisitions worth billions were part of this wintry time. Moreover, biotech deals in antibody-drug conjugates, small molecules, antibody therapies, GLP-1 agonists, and precision medicine stood out in November 2024.Top M&As of November 2024One of the biggest buyouts last month was Swiss pharma giant Roche’s $1.5 billion dollar acquisition of cell and gene therapy developer Poseida Therapeutics. This will see Roche nab the CAR-T…

Post provided by Matthew Lattanzio. Hello there! My name is Matthew Lattanzio, and I am an Associate Professor at Christopher Newport University where I study how reptiles and amphibians interact with and respond to environmental variability. I grew up as a nature enthusiast, and so it is exciting to still carry that curiosity through to my career, constantly challenging myself and my students to think broadly about biological phenomena and most importantly, think outside the box. My latest project, described in a recent Methods in Ecology and Evolution paper, started with a simple question: Why isn’t ultraviolet (UV) light studied…

There is a constant risk of severe, potentially life-threatening allergic reactions for individuals with peanut allergies, which leads to significant physical, social, and emotional burdens.IgGenix, a clinical-stage immunology biotechnology company, recently announced the first patient dosed in its phase 1 trial evaluating IGNX001, a novel monoclonal antibody-based therapeutic, for peanut allergy. Designed to neutralize the most clinically important peanut allergens and epitopes, IGNX001 combats peanut allergies by blocking the allergic cascade and reducing risk of anaphylaxis.Should IGNX001 prove successful, it will provide a promising solution for peanut allergies and pave the way for IgGenix’s technology to be applied to other types…